Biarylpyrimidines: a new class of ligand for high-order DNA recognition

Description

No / Biarylpyrimidines bearing ω-aminoalkyl substituents have been designed as ligands for high-order DNA structures: spectrophotometric, thermal and competition equilibrium dialysis assays showed that changing the functional group for substituent attachment from thioether to amide switches the structural binding preference from triplex to tetraplex DNA; the novel ligands are non-toxic and moderate inhibitors of human telomerase.

Links & Downloads

1. Murphy PM, Phillips VA, Jennings SA, et al (2003) Biarylpyrimidines: a new class of ligand for high-order DNA recognition. Chemical Communications. 2003 (10): 1160-1161.
2. http://hdl.handle.net/10454/3145
3. https://doi.org/10.1039/b301554h

Tags

Biaryl pyramidines

Ligands

DNA-recognition

Additional Fields

Identifer	oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/3145
Date	January 2003
Creators	Murphy, Peter M., Phillips, Victoria A., Jennings, Sharon A., Garbett, N.C., Chaires, J.B., Jenkins, Terence C., Wheelhouse, Richard T.
Source Sets	Bradford Scholars
Language	English
Detected Language	English
Type	Article, No full-text in the repository