A classification procedure was developed that uses hidden Markov models (HMMs) to identify sub-groups within a chronic lower back pain (CLBP) patient population based on their time series of lifting patterns during a repetitive lifting task. Based on clinical observations of a repetitive lifting task, our approach assumed that the patient population was composed of two groups: one group that performed lifts more similar to controls than to other patients and another group that lifted differently from control subjects. Two HMMs were designed to describe the repetitive lifting data, one derived from the control subject data and one derived from the CLBP subject data. The HMMs were designed based on the results of a data reduction procedure that reduced and combined the multidimensional lifting parameters into discrete lifting patterns using factor analysis and cluster analysis.
Simulation studies were performed to demonstrate that the HMMs could reliably identify subjects from one group that were intentionally mislabeled as the other group. When the HMMs were applied to clinical data, 35 of the 81 CLBP subjects were classified to the control HMM and 46 were classified to the CLBP HMM. For the control group, 46 of 53 control subjects were classified to the control HMM and only seven were classified to the CLBP HMM. The CLBP groups were found to use different lifting patterns during the task. The CLBP subjects that were classified to the CLBP HMM were found to use a lifting pattern that involves slow, controlled movements. Self-reported measures of the two groups of CLBP subjects were compared and self-reported pain intensity, pain severity and perceived self-efficacy found to be statistically different. The CLBP subjects that were classified to the CLBP HMM reported higher pain intensity and pain severity, and lower self-efficacy suggesting that the CLBP population is heterogeneous and that the HMM classification procedure can successfully identify two meaningfully different sub-groups of CLBP patients.
| Identifer | oai:union.ndltd.org:PITT/oai:PITTETD:etd-03162007-163608 |
| Date | 12 June 2007 |
| Creators | Slaboda, Jill Christina |
| Contributors | Rory Cooper, PhD, Thomas Rudy, PhD, J.Robert Boston, PhD, Mark Miller, PhD, Amro El-Jaroudi, PhD, Mark Redfern, PhD |
| Publisher | University of Pittsburgh |
| Source Sets | University of Pittsburgh |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.pitt.edu/ETD/available/etd-03162007-163608/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to University of Pittsburgh or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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