Clinical and engineering studies of carotid artery disease typically assume that the
common carotid artery (CCA), proximal to the bifurcation, is relatively straight enough to
assume fully-developed flow. However, a recent study from our group (Ford et al)
showed the surprising presence, in vivo, of strongly skewed velocity profiles in mildly
curved CCAs. In this thesis we aim to understand how CCA geometry affects velocity
profile skewing.
The left and right normal CCAs of 32 participants (62±13 yrs), randomly chosen
from NIH’s VALIDATE study (N~450) were digitally segmented from aortic root to
bifurcation. It was shown that each segmented CCA could be divided into nominal
cervical and thoracic region and that each region could be approximated by planar
circular arches. Subsequent CFD simulations of CCA parametric models suggested
strong velocity profile skewing both at the inlet and outlet of cervical segment and the
effect of various geometric parameters were investigated.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:OTU.1807/25845 |
| Date | 12 January 2011 |
| Creators | Manbachi, Amir |
| Contributors | Steinman, David |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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