Raman Spectroscopy has been shown to have the potential for providing differential diagnosis in the cervix with high sensitivity and specificity in previous in vitro and in vivo studies. Two clinical studies further evaluated the potential of near infrared Raman spectroscopy to detect cervical dysplasia in a clinical setting. In the first study, the Raman spectral features of the different pathologies found in the cervix were characterized and mathematical algorithms were developed to classify the spectra according to pathology. The second study examined and quantified the sources of spectral variability within a given pathology. Experiments using organotypic raft cultures examined the biochemical and cellular basis for the spectral differences seen between normal and dysplastic tissue. These studies have laid the foundation for the development of Raman spectroscopy as a non-invasive, real-time diagnostic tool for cervical dysplasia.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-03292004-210143 |
| Date | 04 May 2004 |
| Creators | Viehoever, Amy Robichaux |
| Contributors | Lynn Matrisian, Robert Roselli, Howard Jones, Anita Mahadevan-Jansen |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-03292004-210143/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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