Most functional MRI studies rely on fast Echo Planar Imaging, which is sensitive to magnetic susceptibility effects. These effects can lead to image-to-image signal instability, reducing the reliability of functional activation maps. Respiration is responsible for a significant component of image-to-image variance, but no widely effective method for correcting respiration-based susceptibility effects is available.
We demonstrate a relationship between respiration-related susceptibility effects in the presence of parallel imaging acquisitions and apply our findings to analyze the behavior of IMPACT (IMage-based Physiological Artifact Correction Technique). Based on our findings regarding IMPACT, we propose COMPACT (Center of Mass-based Physiological Artifact Correction Technique), a new method which provides a reliable estimate of respiratory effects based on the motion of an image sets center of mass (centroid) through time.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-11302006-141540 |
| Date | 06 December 2006 |
| Creators | Sexton, John Andrew |
| Contributors | John Gore, Chris Gatenby |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-11302006-141540/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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