This thesis is concerned with the quantification of cardiac longitudinal relaxation (T1) at 3.0 T. Normal and hyperoxic T1 are quantified in the myocardium and left ventricular blood pool of healthy volunteers using the Modified Look-Locker Inversion recovery (MOLLI) technique. Change in mean myocardial T1 with hyperoxia at 3.0 T is compared to similar results at lower field strengths. Three alternative T1 quantification techniques based on the original MOLLI sequence are presented and evaluated along with the original MOLLI sequence for accuracy and consistency in measuring T1 values expected in the myocardium and blood at 3.0 T. Additionally, a theoretical model predicting the reduction in myocardial T1 with an intravascular contrast agent is examined for applicability to oxygen as a contrast agent. The results of this theoretical model are compared to experimental results obtained in this study.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-07252008-141830 |
| Date | 03 August 2008 |
| Creators | Hilt, Paul James |
| Contributors | Cynthia Paschal |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-07252008-141830/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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