Engineered nanomaterials have structural features with at least one dimension in the 1?100 nm range. Because of their small size, nanoparticles possess unique chemical, mechanical, electrical, optical, magnetic, and biological properties that make them ideal candidates for a variety of novel commercial and medical applications. Particularly, carbon-based nanomaterials such as fullerenes, nanotubes, and nanowires are considered key elements in the development of new nano-applications with the potential to be used in everything from biomedicine and drug delivery systems to nanoelectronics and energy conservation mechanisms. Relatively unknown, however, is how exposure to nanoscale particles effects normal biological functions and processes. A major focus of recent toxicological research has begun to investigate the interactions between the biological environment and engineered nanoparticles and to determine appropriate safety standards that should be considered when interacting with nanomaterials. The purpose of this research is to investigate how fullerene-based amino acids interact with the biological environment both at the tissue and cellular levels and to identify factors, such as mechanical stimulation, that increase these interactions.
| Identifer | oai:union.ndltd.org:NCSU/oai:NCSU:etd-03212007-144330 |
| Date | 06 April 2007 |
| Creators | Rouse, Jillian Grace |
| Contributors | Peter L. Mente, Elizabeth G. Loboa, Nancy A. Monteiro-Riviere |
| Publisher | NCSU |
| Source Sets | North Carolina State University |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://www.lib.ncsu.edu/theses/available/etd-03212007-144330/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dis sertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to NC State University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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