Abstract: Clavulanic acid is a β‐lactamase inhibitor which prevents microbial lactamase inactivation of β‐lactam antibiotics. The pharmacokinetics and urinary excretion of clavulanic acid were studied in eight healthy adult volunteers after oral administration of 500 mg amoxicillin and 125 mg potassium clavulanate. Serum and urine clavulanic acid concentrations were assayed using high‐performance liquid chromatography. Pharmacokinetic parameters were: t1/2β = 1.019 ± 0.090 hour, t1/2α = 0.276 ± 0.031 hour, lag time = 0.321 ± 0.018 hour, tmax = 1.042 ± 0.80 hour, Cmax = 2.098 ± 0.441 μg/ml, and AUC = 4.897 ± 0.979 μg · hr/ml. Cumulative urinary excretion of clavulanic acid (as percentage of dose administered) was: 14.05 ± 2.87 within 2 hours, 25.77 ± 3.98 within 4 hours, and 27.85 ± 4.27 within 6 hours after administration.
Identifer | oai:union.ndltd.org:ETSU/oai:dc.etsu.edu:etsu-works-13823 |
Date | 01 January 1984 |
Creators | FERSLEW, KENNETH E., DAIGNEAULT, ERNEST A., ATEN, EDWARD M., ROSEMAN, JAMES M. |
Publisher | Digital Commons @ East Tennessee State University |
Source Sets | East Tennessee State University |
Detected Language | English |
Type | text |
Source | ETSU Faculty Works |
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