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ADDITIVE MANUFACTURING TECHNOLOGIES FOR FLEXIBLE OPTICAL AND BIOMEDICAL SYSTEMS

<p>Advances in additive
manufacturing technologies enable the rapid, high-throughput generation of mechanically
soft microelectromechanical devices with tailored designs for many applications
spanning from optical to biomedical applications. These devices can be softly
interfaced with biological tissues and mechanically fragile systems, which
enables to open up a whole new range of applications. However, the scalable
production of these devices faces a significant challenge due to the complexity
of the microfabrication process and the intolerable thermal, chemical, and
mechanical conditions of their flexible polymeric substrates. To overcome these
limitations, I have developed a set of advanced additive manufacturing
technologies enabling (1) mechanics-driven
manufacturing of quasi-three-dimensional (quasi-3D) nanoarchitectures with
arbitrary substrate materials and structures; (2) repetitive replication of quasi-3D
nanoarchitectures for infrared (IR) bandpass filtering; (3) electrochemical
reaction-driven delamination of thin-film electronics over wafer-scale; (4)
rapid custom printing of soft poroelastic materials for biomedical
applications. </p>

<p>First, I have developed a new
mechanics-driven nanomanufacturing method enabling large-scale production of
quasi-3D plasmonic nanoarchitectures that are capable of controlling light at
nanoscale length. This method aims to eliminate the need for repetitive uses of
conventional nanolithography techniques that are time- and cost-consuming. This
approach is innovative and impactful because, unlike any of the conventional manufacturing
methods, the entire process requires no chemical, thermal, and mechanical
treatments, enabling a large extension of types of receiver substrate to nearly
arbitrary materials and structures. Pilot deterministic assembly of quasi-3D
plasmonic nanoarrays with imaging sensors yields the most important advances,
leading to improvements in a broad range of imaging systems. Comprehensive
experimental and computational studies were performed to understand the underlying
mechanism of this new manufacturing technique and thereby provide a
generalizable technical guideline to the manufacturing society. The constituent
quasi-3D nanoarchitectures achieved by this manufacturing technology can
broaden considerations further downscaled plasmonic metamaterials suggest
directions for future research.</p>

<p>Second, I have developed mechanics-driven
nanomanufacturing that provides the capability to repetitively replicate quasi-3D
plasmonic nanoarchitectures even with the presence of an extremely brittle
infrared-transparent spacer, such as SU-8, thereby manipulating IR light (e.g.,
selectively transmitting a portion of the IR spectrum while rejecting all other
wavelengths). Comprehensive experimental and computational studies were
performed to understand the underlying nanomanufacturing mechanism of quasi-3D
plasmonic nanoarchitectures. The spectral features such as the shape of the
transmission spectrum, peak transmission and full width at half maximum (FWHM),
etc. were studied to demonstrate the bandpass filtering effect of the assembled
quasi-3D plasmonic nanoarchitecture.</p>

<p>Third, I have developed an
electrochemical reaction-driven transfer printing method enabling a one-step
debonding of large-scale thin-film devices. Conventional transfer printing
methods have critical limitations associated with an efficient and intact
separation process for flexible 3D plasmonic nanoarchitectures or
bio-integrated electronics at a large scale. The one-step electrochemical
reaction-driven method provides rapid delamination of large-scale quasi-3D
plasmonic nanoarchitectures or bio-integrated electronics within a few minutes
without any physical contact, enabling transfer onto the target substrate
without any defects and damages. This manufacturing technology enables the rapid
construction of quasi-3D plasmonic nanoarchitectures and bio-integrated
electronics at a large scale, providing a new generation of numerous
state-of-art optical and electronic systems.</p>

<p>Lastly, I have developed a new
printing method enabling the direct ink writing (DIW) of multidimensional
functional materials in an arbitrary shape and size to rapidly prototype stretchable
biosensors with tailored designs to meet the requirement of adapting the
geometric nonlinearity of a specific biological site in the human body. Herein,
we report a new class of a poroelastic silicone composite that is exceptionally
soft and insensitive to mechanical strain without generating significant
hysteresis, which yields a robust integration with living tissues, thereby
enabling both a high-fidelity recording of spatiotemporal electrophysiological
activity and real-time ultrasound imaging for visual feedback. Comprehensive <i>in vitro</i>, <i>ex vivo</i>,
and <i>in vivo</i> studies provide not only to understand the
structure-property-performance relationships of the biosensor but also to
evaluate infarct features in a murine acute myocardial infarction model. These
features show a potential clinical utility in the simultaneous intraoperative
recording and imaging on the epicardial surface, which may guide a definitive
surgical treatment.</p>

  1. 10.25394/pgs.14502510.v1
Identiferoai:union.ndltd.org:purdue.edu/oai:figshare.com:article/14502510
Date28 April 2021
CreatorsBongjoong Kim (10716684)
Source SetsPurdue University
Detected LanguageEnglish
TypeText, Thesis
RightsCC BY 4.0
Relationhttps://figshare.com/articles/thesis/ADDITIVE_MANUFACTURING_TECHNOLOGIES_FOR_FLEXIBLE_OPTICAL_AND_BIOMEDICAL_SYSTEMS/14502510

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