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Methods to study TCDD-inducible poly-ADP-ribose polymerase (TIPARP) mono-ADP-ribosyltransferase activity

No / TCDD-inducible poly-ADP-ribose polymerase (TIPARP; also known as PARP7 and ARTD14) is a
mono-ADP-
ribosyltransferase
that has emerged as an important regulator of innate immunity, stem cell
pluripotency, and transcription factor regulation. Characterizing TIPARP’s catalytic activity and identifying
its target proteins are critical to understanding its cellular function. Here we describe methods that
we use to characterize TIPARP catalytic activity and its mono-ADP-ribosylation of its target proteins.

Identiferoai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/18336
Date11 August 2018
CreatorsHutin, D., Grimaldi, Giulia, Matthews, J.
Source SetsBradford Scholars
LanguageEnglish
Detected LanguageEnglish
TypeBook chapter, No full-text in the repository

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