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Synthesis Of Bishomo-inositol Derivatives

Inositols belong to an important class of biologically active compounds, named as
cyclitols (cyclic polyols), which have attributed high interest in the past decade due
to the glycosidase inhbition property that affects many biological processes.
Initially, 1,3,3a,7a-tetrahydro-2-benzofuran (69) was synthesized as a key compound
to synthesize bishomo-inositol derivatives. Then photooxygenation and
manganese(III) acetate oxidation reactions of this key compound were studied in
order to obtain isomeric inositol derivatives. Moreover, dihydroxylation and acid
catalyzed ring opening reactions were investigated. Finally, new synthetic
approaches for the synthesis of bishomo-inositol derivatives have been developed. In
addition to that whole products were conscientiously purified and characterized and
mechanism for the formation of the products has been discussed.

Identiferoai:union.ndltd.org:METU/oai:etd.lib.metu.edu.tr:http://etd.lib.metu.edu.tr/upload/12613735/index.pdf
Date01 October 2011
CreatorsBekarlar, Merve Gokcen
ContributorsBalci, Metin
PublisherMETU
Source SetsMiddle East Technical Univ.
LanguageEnglish
Detected LanguageEnglish
TypeM.S. Thesis
Formattext/pdf
RightsTo liberate the content for public access

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