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Synthesis of new DNA-Binding Agents with polyamide moiety

Synthetic netropsin analogs of the thiophene and pyridine, induce the netropsin analogs binding DNA from A-T base pair change to G-C base pair. Moreover, dendritic electrostatic groups have bulky conformation, which induce the netropsin analogs binding DNA to major groove.

Identiferoai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0705103-230523
Date05 July 2003
CreatorsLai, Ming-Chi
ContributorsMing-Jung Wu, Cherng-Chyi Tzeng, Chi-Wi Ong, Wen-Jwu Wang, Chien-Chung Cheng, Leung Sheh
PublisherNSYSU
Source SetsNSYSU Electronic Thesis and Dissertation Archive
LanguageCholon
Detected LanguageEnglish
Typetext
Formatapplication/pdf
Sourcehttp://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0705103-230523
Rightsoff_campus_withheld, Copyright information available at source archive

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