The product of transmembrane and coiled-coil domains 1 (TMCO1) gene is a
member of several eukaryotic proteins with unknown function. In a preliminary
Bioinformatics and Stanford Microarray Database data-mining and some of our
preliminary data, transmembrane and coiled-coil domains 1 (TMCO1)
immunohistochemistry (IHC) was identified to be up-regulated in non-invasive
bladder cancer. To further studies on the functions and regulatory mechanisms
the role of TMCO1 gene. In the present study, we examined the TMCO1
expression levels in human bladder cell lines, RT4, TSGH8301, J82. We
observed TMCO1 high expression in RT4 and low expression in TSGH8301.
We investigate overexpression and knock down of TMCO1in RT4 and
TSGH8301. Further we study the expression change of TOMCO1 how to change
cell function and morphology. In this study, we can get transfection of shRNA
interference targeting TMCO1 in RT4 cell enhanced cell proliferation.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0908110-115659 |
| Date | 08 September 2010 |
| Creators | Wang, Wen-tzu |
| Contributors | Ming-Hong Tai, Shiue Yow Ling, Hurng-Wern Huang |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0908110-115659 |
| Rights | not_available, Copyright information available at source archive |
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