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Pharmacological differentiation of species-typical and instrumental responding in mice with septal lesions/

The effect of the dopaminergic drugs amphetamine and pimozide on reinforced and non-reinforced species-typical responding was observed in normal mice and mice with lesions of the septal area. In Experiment 1 amphetamine increased wheel running in the reinforced groups with septal lesioned subjects showing greater enhancement than normal animals. Amphetamine depressed wheel running in non-reinforced septal animals and had no effect on non-reinforced normals. Pimozide decreased wheel running in all groups. In Experiment 2, amphetamine increased string pulling in reinforced normal and septal lesioned mice, but this increase was not dose dependent. Non-reinforced septal and normal animals exhibited amphetamine induced decreases in response rate. Again pimozide decreased string pulling in all groups.

Identiferoai:union.ndltd.org:UMASS/oai:scholarworks.umass.edu:theses-2405
Date01 January 1982
CreatorsPowell, Anne E.
PublisherScholarWorks@UMass Amherst
Source SetsUniversity of Massachusetts, Amherst
Detected LanguageEnglish
Typetext
Formatapplication/pdf
SourceMasters Theses 1911 - February 2014

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