The primary purpose of this study was to investigate the effects of aerobic and
resistance training on BDNF and IGF-I expression in a 3xTg-AD mouse model of
Alzheimer’s disease. Twenty-four 3xTg-AD mice were randomly assigned to either an
aerobic (AT, n=8), resistance (RT, n=8), or control (CNT, n=8) group. Intervention
groups underwent 9 weeks of exercise training. Motor behavior and grip strength were
measured pre- and post- intervention. Our results showed a significant increase in
hippocampal BDNF expression in AT mice after a 9-week intervention. Further, AT mice
were found to have higher concentrations of IGF-I, and improved motor behavior when
compared to RT and CNT. No significant differences were observed in IGF-I
concentration between RT and other groups. RT improved grip strength after nine weeks
of training. These findings support the use of AT and RT as a tool to improve
comorbidities found in Alzheimer’s disease. / Includes bibliography. / Thesis (M.S.)--Florida Atlantic University, 2018. / FAU Electronic Theses and Dissertations Collection
| Identifer | oai:union.ndltd.org:fau.edu/oai:fau.digital.flvc.org:fau_40750 |
| Contributors | Pena, Gabriel S. (author), Whitehurst, Michael (Thesis advisor), Florida Atlantic University (Degree grantor), College of Education, Department of Exercise Science and Health Promotion |
| Publisher | Florida Atlantic University |
| Source Sets | Florida Atlantic University |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation, Text |
| Format | 56 p., application/pdf |
| Rights | Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder., http://rightsstatements.org/vocab/InC/1.0/ |
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