A bilateral salpingo oophorectomy (BSO), removal of the ovaries, is recommended for carriers of BRCA1/2 mutations to reduce cancer risks. However, BSO induces surgical menopause, and is associated with an increased risk of dementia (Rocca et al., 2007a) and Parkinsonism (Rocca et al, 2007b). This study investigated the cognitive outcomes of BSO one to ten years post-surgically. The present dataset (n=37) revealed there was a significant difference between the BSO group and their age matched cohort on the Logical Memory task assessing verbal, episodic memory. Levels of E1G (estrogen metabolite) was a significant predictor of the RAVLT primacy subscale indicating higher levels were associated with better recall at the beginning of a list of words. Controlling for age, performance on the RAVLT A1 measuring short-term memory degraded further out from BSO. While limited by the sample size, results are consistent with reports of post-BSO cognitive changes (Vearncomb & Panchana, 2009).
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/33327 |
| Date | 20 November 2012 |
| Creators | Au, Sin Tung |
| Contributors | Einstein, Gillian |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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