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Previous issue date: 2017-12-15 / Breast cancer is the second most common type of cancer in the world, and the most common among women, affecting men who account for 1% of all cases of the disease. The risk factors of the disease are related to age, endocrine / reproductive history, behavioral / environmental factors, and genetic / hereditary factors. The prognosis of the disease depends on its extension (staging), with greater curative potential when diagnosed at baseline.Among the types of treatment of breast cancer stand out surgery, radiotherapy, chemotherapy, hormone therapy and biological therapy. It is highlighted in the radiotherapy modality, Brachytherapy, which is the application of radiation in a more precise and localized way in the tumor. In this work we will focus on high-grade interstitial brachytherapy dose rate, partial and accelerated breast irradiation (IPAM), which has been shown to have better esthetic results, lower risk of injury from radiation from healthy adjacent tissues, shorter duration of treatment, and low recurrence rates. This is a retrospective, longitudinal, descriptive, analytical study, with a review of medical records of patients diagnosed with breast cancer, stages 0-I-II, between the years 2004 and 2013 who received IPAM using brachytherapy after conservative surgery of the breast at the Radium Institute of Campinas, Campinas-SP, Brazil.This work aims to report and evaluate the viability, acute and chronic toxicity, aesthetic aspects, efficacy and factors related to the use of Partial and Accelerated Breast Irradiation with high dose rate brachytherapy for patients with early stage of breast cancer. In addition to assessing recurrence rates and local control of the disease. / O c?ncer de mama ? o segundo tipo de c?ncer mais comum no mundo,e o mais frequente entre as mulheres, acometendo tamb?m homens que representam 1% do total de casos da doen?a. Os fatores de risco da doen?a est?o relacionados com idade, fatores end?crinos/hist?ria reprodutiva, fatores comportamentais/ambientais e fatores gen?ticos/heredit?rios. O progn?stico da doen?a depende da sua extens?o (estadiamento), com maior potencial curativo quando diagnosticada no in?cio. Entre os tipos de tratamento do c?ncer de mama destacam-se a cirurgia, radioterapia , quimioterapia, hormonioterapia e terapia biol?gica. Apresenta destaque na modalidade radioter?pica, a Braquiterapia, que trata-se da aplica??o de radia??o de forma mais precisa e localizada no tumor. Neste trabalho teremos como enfoque a braquiterapia intersticial de alta taxa de dose, irradia??o parcial e acelerada da mama (IPAM), que vem apresentando melhores resultados est?ticos, menor risco de les?o pela radia??o de tecidos adjacentes saud?veis, menor dura??o do tratamento, e baixas taxas de recorr?ncia. Trata-se de um estudo retrospectivo, longitudinal, descritivo, anal?tico, com revis?o de prontu?rios de pacientes com diagn?stico de c?ncer de mama, est?dios 0-I-II , entre os anos de 2004 e 2013 que receberam IPAM utilizando braquiterapia ap?s a cirurgia conservadora da mama no Instituto do Radium de Campinas, Campinas-SP, Brasil. Tal trabalho objetiva relatar e avaliar a viabilidade, toxicidade aguda e cr?nica, aspectos est?ticos, efic?cia e fatores relacionados com utiliza??o de Irradia??o Parcial e Acelerada da Mama com braquiterapia de alta taxa de dose para pacientes com est?dio inicial de c?ncer de mama. Al?m de avaliar as taxas de recorr?ncia e controle local da doen?a.
| Identifer | oai:union.ndltd.org:IBICT/oai:tede.bibliotecadigital.puc-campinas.edu.br:tede/1005 |
| Date | 15 December 2017 |
| Creators | Massarotto, Ana Carolina |
| Contributors | Reis, Leonardo Oliveira, Schultz, Luciana, Bueno, M?rcia Pereira |
| Publisher | Pontif?cia Universidade Cat?lica de Campinas, Programa de P?s-Gradua??o em Ci?ncias da Sa?de, PUC-Campinas, Brasil, CCV ? Centro de Ci?ncias da Vida |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da PUC_CAMPINAS, instname:Pontifícia Universidade Católica de Campinas, instacron:PUC_CAMP |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 6411916762624721206, 500, 500, -8538742193007695607 |
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