Indiana University-Purdue University Indianapolis (IUPUI) / This study was undertaken to investigate histologically the
effect of a combination of a potent antibiotic and calcium hydroxide
when used as a medication in direct pulp therapy.
The pulps of 74 teeth in one Macaca Speciosa monkey and
two Macaca Nemestrina monkeys were exposed and left open to the
oral environment for 48 hours to insure contamination. These
pulps received direct treatment with one of four experimental
medications: 1) starch and water; 2) vancomycin, starch and
water; 3) calcium hydroxide, methyl cellulose and water; and
4) vancomycin, calcium hydroxide, methyl cellulose and water.
In 30 days the teeth were removed from two animals and at 90
days from the other for histologic evaluation.
A satisfactory response was observed in all the teeth
treated with vancomycin, calcium hydroxide, methyl cellulose and
water; in 94.4 per cent of the teeth treated with calcium hydroxide, methyl cellulose and water; in 33.3 per cent of those treated with vancomycin and starch; and in 11.2 per cent of those receiving starch and water. Complete bridging was seen
in all teeth treated with vancomycin, calcium hydroxide, methyl
cellulose and water. This was confirmed by the use of Procion
brilliant red H-8BS dye and the study of serial sections.
Under the conditions of this investigation, vancomycin in
combination with calcium hydroxide and methyl cellulose was
effective in controlling infection and promoting reparative
dentin formation in monkeys.
| Identifer | oai:union.ndltd.org:IUPUI/oai:scholarworks.iupui.edu:1805/3544 |
| Date | January 1969 |
| Creators | Gardner, Donald E. |
| Source Sets | Indiana University-Purdue University Indianapolis |
| Language | en_US |
| Detected Language | English |
| Type | Thesis |
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