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CalciumSim: Simulator for calcium dynamics on neuron graphs using dimensionally reduced model

Calcium signaling has been identified with triggering of gene transcriptions associated with learning and neuroprotection in neurons. Studies indicate that dysregulation of calcium signaling is correlated with severe Alzheimer Disease pathologies. A stable calcium wave or signal arising from triggers in dendritic synapses needs to reach soma with constant amplitude for proper functioning of neurons. In this study, we introduce "CalciumSim", a calcium dynamics simulator which works on dimensionally reduced model. Numerical analysis is conducted to obtain the best configuration of neuron geometry to make the code efficient and fast. Alongside, biologically important insights are derived by modulating and changing parameters of the simulation. The ability of "CalciumSim" to work with real neuron geometries allows user to study calcium signalling in a realistic model. / Mathematics

Identiferoai:union.ndltd.org:TEMPLE/oai:scholarshare.temple.edu:20.500.12613/7671
Date January 2022
CreatorsBorole, Piyush, 0000-0003-3327-5847
ContributorsQueisser, Gillian, Seibold, Benjamin, Yilmaz, Atilla, Picone, Joseph
PublisherTemple University. Libraries
Source SetsTemple University
LanguageEnglish
Detected LanguageEnglish
TypeThesis/Dissertation, Text
Format74 pages
RightsIN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available., http://rightsstatements.org/vocab/InC/1.0/
Relationhttp://dx.doi.org/10.34944/dspace/7643, Theses and Dissertations

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