Intestinal homeostasis relies on complex interactions between the intestinal epithelium, microbiota, and host immune system, all of which cooperate to maintain homeostasis in an environment colonized and challenged by an estimated 100 trillion bacteria. It is the disruption and dysregulation of these interactions that is currently thought to underlie intestinal pathologies such as inflammatory bowel disease (IBD) and colorectal cancer (CRC). The Myeloid translocation gene (MTG) family of transcriptional corepressors and the tight-junction associated protein Blood vessel epicardial substance (BVES) have been shown to be important regulators of the intestinal epithelium. I hypothesized that loss of MTG or BVES function play important roles in IBD and CRC. Using genetic mouse models, cell lines, and organoid cultures, we clarified the role MTGs and BVES play in intestinal pathologies by identifying their binding partners and what signaling pathways they regulate. Overall, the primary objective of my work was to further elucidate the functional role of MTGs and BVES in the intestinal epithelium and carcinogenesis.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-06222015-120937 |
| Date | 14 July 2015 |
| Creators | Parang, Bobak |
| Contributors | Christopher Williams, Barbara Fingleton, Keith Wilson, David Bader, Daniel Beauchamp |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-06222015-120937/ |
| Rights | restricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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