Cardiac dysfunction accelerates the risk of heart failure, and its pathogenesis involves a
complex interaction between genetic and environmental factors. Variations in myosin affect contractile
abilities of cardiomyocytes and cause structural and functional abnormalities in myocardium. The
study aims to find the association of MYH7 rs121913642 (c.1594 T>C) and rs121913645 (c.667G>A)
variants with cardiac dysfunction in the Punjabi Pakistani population. Patients with heart failure
(n = 232) and healthy controls (n = 205) were enrolled in this study. MYH7 variant genotyping
was performed using tetra ARMS-PCR. MYH7 rs121913642 TC genotype was significantly more
prevalent in the patient group (p < 0.001). However, MYH7 rs121913645 genotype frequencies
were not significantly different between the patient and control groups (p < 0.666). Regression
analysis also revealed that the rs121913642 C allele increases the risk of cardiac failure by ~2 [OR:1.98,
CI: 1.31–2.98, p < 0.001] in comparison to the T allele. High levels of the cardiac enzymes cardiac
troponin I (cTnI) and CK-MB were observed in patients. There was also an increase in total cholesterol,
LDL cholesterol, and uric acid in patients compared to the healthy control group (p < 0.001). In
conclusion, the MYH7 gene variant rs121913642 is genetically associated with cardiac dysfunction
and involved in the pathogenesis of HF.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:88424 |
| Date | 04 December 2023 |
| Creators | Yousaf, Memoona, Khan, Waqas Ahmed, Shahzad, Khurrum, Khan, Haq Nawaz, Ali, Basharat, Hussain, Misbah, Awan, Fazli Rabbi, Mustafa, Hamid, Sheikh, Farah Nadia |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 2073-4425, 10.3390/genes13091554 |
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