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The Effects of Hypothermia on the Release of Cardiac Enzymes

The myocardium is known to release CPK, LDH1 , and GOT in response to ischemia as a result of myocardial infarction. This study was designed to induce the release of cardiac enzymes without adversely effecting the myocardium by perfusion hypothermia, thereby suggesting that these enzymes are not as specific in the diagnosis of myocardial infarction as once thought.
Hypothermia was by in vivo perfusion of the left anterior descending coronary artery. Enzyme activity was measured from sera samples spectrophotometrically and electrophoretically. Significant CPK and LDH1 increases were observed in animals perfused between 25 and 19 C. These results indicate that, while heart function remained unchanged, an alteration occurred in the membrane integrity of the myocardial cells.

Identiferoai:union.ndltd.org:unt.edu/info:ark/67531/metadc662977
Date08 1900
CreatorsStrawn, William B.
ContributorsRedden, David R., Lott, James R., Schafer, Rollie
PublisherNorth Texas State University
Source SetsUniversity of North Texas
LanguageEnglish
Detected LanguageEnglish
TypeThesis or Dissertation
Formatv, 61, [7] leaves : ill., graphs, Text
RightsPublic, Strawn, William B., Copyright, Copyright is held by the author, unless otherwise noted. All rights

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