Orientador: Pedro Henrique Saldanha / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-07-16T14:52:57Z (GMT). No. of bitstreams: 1
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Previous issue date: 1986 / Resumo: Não informado / Abstract: Dermatoglyphics of the 183 patients with congenital heart disease (CHD), their parents and brothers and a sample of 170 subjects of the normal populations of são Paulo were studied. The propositi were patients of the Clinical Hospital of the Faculty of Medicine of the University
of são Paulo, with diagnoses established through surgical treatment and clinical criteria such as electrocardiographic, roentgenologic and haemodinamic studies; no case with doubtful diagnosis was included. Informations concerning to sex, race, type of CHD, age of the parents by the time of birth, presence of CHD or another congenital malformations in the relatives, birth order of the propositi, number of abórtion and/or fetal deaths, expositionto the X-rays, infeccious diseases and use of drugs by their mothers during the first, three months of pregnancy. The following dermatoglyphic features were analised: total ridge count (TRC) in the fingers, a-b ridge count, atd angle, ulnar index, number of digital,sub-digital and axial triradii, and ridge count of the halux in the solar area. The statistical treatment consisted in the elaboration of frequency tables and distribution curves, means and their standard errors, analysis of variance between groups and intra-individual correlation coefficients between the different traits. The results allow the following eonelusions: 1. The reeurrenee of the CHD in the relatives suggest the existenee of hereditary faetorspredisposing the development of those anomalies. 2. The high eonsanguinity rate between the propositios parents suggest the existenee of recessive genes participating in the heredity of CHD. 3. The total ridge count on fingers and on the halux are a of the propositi are not significantly different from that of normal population. 4. The a-b ridge count is significantly higher in the propositi and their relatives. 5. The maximum atd anglereveals a statistically significant distal displacement of the axial palmar triradius' in the propositi and in their brothers. 6. The ulnar index reveals a highly significant radial displacement of the axial palmar triradius in the propositi and in their relatives, characterizing them as a group differentiated from the normal population. 7. The correlations between atd angle and ulnar index were highly significant in the relatives of the propositi but not significant in the normal population. This situation suggests that the genic constellation present in the related groups determine pleiotropically a distortion in the displacement of the axial. palmar triradius to the radial
side. 8. The large number of significant and highly significant correlations in the propositi and in their normal relatives reveals that these groups share specific genic constellation which, besides determining a larger number of dermatoglyphic associations, it should predispose to cardiac teratogenesis during the critical period of embryogenic development common to the both structures / Mestrado / Mestre em Biologia e Patologia Buco-Dental
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.unicamp.br:REPOSIP/288499 |
| Date | 26 November 1986 |
| Creators | Castillo Salgado, Miguel Angel |
| Contributors | UNIVERSIDADE ESTADUAL DE CAMPINAS, Saldanha, P. H, Saldanha, Pedro Henrique |
| Publisher | [s.n.], Universidade Estadual de Campinas. Faculdade de Odontologia de Piracicaba, Programa de Pós-Graduação em Biologia e Patologia Buco-Dental |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | 131f., application/pdf |
| Source | reponame:Repositório Institucional da Unicamp, instname:Universidade Estadual de Campinas, instacron:UNICAMP |
| Rights | info:eu-repo/semantics/openAccess |
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