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Myokine Cathepsin B Expression with Exercise Training in the 3xTg-AD Murine Model of Alzheimer’s Disease

This research investigated the relationship between exercise training and
cathepsin B expression in the 3xTg-AD murine model of Alzheimer’s disease. 3xTg-AD
mice were assigned to control (Tg, n=10), aerobic training (Tg+AT, n=10), or resistance
training (Tg+RT, n=10). RotaRod peak latency and grip strength were assessed as preand
post-measurements. Skeletal muscle was collected after training and analyzed for
cathepsin B protein. Tg+RT showed greater grip strength than Tg and Tg+AT at posttesting
(p ≤ 0.05). Only Tg+AT showed an improvement in RotaRod peak latency (p ≤
0.05). Gastrocnemius weight was greater in Tg+RT compared to Tg (p ≤ 0.05), and no
differences were observed in cathepsin B or procathepsin B expression (p > 0.05). This
data suggests that cathepsin B was not induced by either mode of exercise training,
however, physical function and muscle mass were improved, therefore inclusion of both
training modalities may address peripheral comorbidities in Alzheimer’s disease. / Includes bibliography. / Thesis (M.S.)--Florida Atlantic University, 2018. / FAU Electronic Theses and Dissertations Collection

Identiferoai:union.ndltd.org:fau.edu/oai:fau.digital.flvc.org:fau_40748
ContributorsPaez, Hector G. (author), Khamoui, Andy V. (Thesis advisor), Florida Atlantic University (Degree grantor), College of Education, Department of Exercise Science and Health Promotion
PublisherFlorida Atlantic University
Source SetsFlorida Atlantic University
LanguageEnglish
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation, Text
Format51 p., application/pdf
RightsCopyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder., http://rightsstatements.org/vocab/InC/1.0/

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