Solid-phase synthesis of C-terminal thio-linked glycopeptides

Description

No / A solid-phase Mitsunobu reaction between a resin-bound 1-thiosugar and an N-Fmoc protected amino alcohol was successfully employed for thio-linked glycopeptide synthesis. Facile cleavage and deprotection in one step afforded the target glycopeptide in good yield and purity.

Links & Downloads

1. Falconer, R.A. and Malkinson, J.P. (2002). Solid-phase synthesis of C-terminal thio-linked glycopeptides. Tetrahedron Letters. Vol. 43, No. 52, pp. 4549-9552.
2. http://hdl.handle.net/10454/4140
3. https://doi.org/10.1016/S0040-4039(02)02419-X

Tags

Succinate

Amino Acid

Alcohol

Polystyrene

Glycosylation

Cell Differentiation

Cell Adhesion

Cell Recognition

Additional Fields

Identifer	oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/4140
Date	January 2002
Creators	Falconer, Robert A., Malkinson, J.P.
Source Sets	Bradford Scholars
Language	English
Detected Language	English
Type	Article, No full-text in the repository