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The dynamics of the MRP1/2 complex and the function of intact MRB1 core for RNA editing in \kur{Trypanosoma brucei}

This thesis describes the dynamics of mitochondrial RNA-binding protein 1 and 2 (MRP1/2) complex in different cell lines of Trypanosoma brucei under an optimized immobilized condition. This study reveals the influence of RNA on the complex's dynamics. Furthermore, the function of RNA-binding complex 1 (MRB1) core has been studied via reverse genetic, biochemical and molecular techniques, with its role in RNA editing being proposed.

Identiferoai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:200900
Date January 2015
CreatorsHUANG, Zhenqiu
Source SetsCzech ETDs
LanguageEnglish
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/doctoralThesis
Rightsinfo:eu-repo/semantics/restrictedAccess

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