This thesis will explore, both generally and very specifically, the role of biomaterials in drug delivery and tissue engineering applications. A novel therapeutic conjugate to treat dry eye disease using hyaluronic acid and sulfadiazine was created and tested using a benzalkonium chloride induced dry eye model. Thermoresponsive hydrogels based around poly(n-isopropylacrylamide) were synthesized to create a potential in situ gelling cell scaffold for cell delivery to the subretinal space. Finally, a mucoadhesive micelle was developed as a platform delivery system to increase bioavailability of drug in anterior segment therapeutics. / Thesis / Doctor of Philosophy (PhD)
| Identifer | oai:union.ndltd.org:mcmaster.ca/oai:macsphere.mcmaster.ca:11375/21977 |
| Date | 11 1900 |
| Creators | Muirhead, Ben |
| Contributors | Sheardown, Heather, Biomedical Engineering |
| Source Sets | McMaster University |
| Language | English |
| Detected Language | English |
| Type | Thesis |
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