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The Effect of Human Alpha Interferon on Rat Kidney Cell Infected with Temperature-Sensitive Mutant of Rous Sarcoma Virus

LA31-NRK and B77-NRK are established cell lines that were normal rat kidney cells transformed with temperature-sensitive mutant (LA31) and wild-type Bratislava 77 (B77) of Rous sarcoma virus. It is recognized that many transformation-induced changes differentiate between normal and transformed cells. Morphology and four parameters of transformed cells such as saturation density, anchorage independence, plasminogen activator, and colony stimulating factor were used as indicators to observe the effect of human alpha interferon on the growth of NRK, LA31-NRK and B77-NRK. The results show that interferon could neither reverse the transformed cells to normal fashion nor change their behaviors or cause release of protease.

Identiferoai:union.ndltd.org:unt.edu/info:ark/67531/metadc504528
Date05 1900
CreatorsChang, Shiuan
ContributorsChen, Young C., Johansson, Karl R.
PublisherNorth Texas State University
Source SetsUniversity of North Texas
LanguageEnglish
Detected LanguageEnglish
TypeThesis or Dissertation
Formatv, 45 leaves : ill., Text
RightsPublic, Chang, Shiuan, Copyright, Copyright is held by the author, unless otherwise noted. All rights reserved.

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