The overall architecture and cell types are highly conserved from mammals to teleost fish. The rapid transparent ex utero development in zebrafish allows direct access and precise visualization of all the major events in cerebellar development. The superficial position of the cerebellar primoridum and cerebellum further facilitates in vivo imaging of cerebellar structures and developmental events at cell resolution. Furthermore, zebrafish model have a comprehensive genetic toolbox that allow forward and reverse genetic approaches to study and manipulate gene function. Consequently, zebrafish is emerging as an excellent vertebrate model for studies of molecular, cellular and physiological mechanisms involved in cerebellar development and function at gene, cell and circuit level.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:33554 |
| Date | 19 March 2019 |
| Creators | Kaslin, Jan, Brand, Michael |
| Publisher | Springer International Publishing Switzerland 2016 |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/acceptedVersion, doc-type:bookPart, info:eu-repo/semantics/bookPart, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 10.1007/978-3-319-24551-5, 978-3-319-24549-2, 978-3-319-24551-5, 10.1007/978-3-319-24551-5_56 |
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