This critical synopsis of prior work by Clive Beggs is submitted in support of a PhD
by published work. The work focuses on venous and cerebrospinal fluid (CSF)
anomalies associated with multiple sclerosis (MS) and other neurological diseases.
MS is characterized by focal inflammatory lesions, which are often venocentric.
Recently a vascular syndrome, chronic cerebrospinal venous insufficiency (CCSVI)
has been linked with MS. This syndrome, which is characterized by constricted
cerebral venous outflow, has become mired in controversy, with various studies
producing conflicting findings, with the result that the science associated with
CCSVI has become obscured.
Clive Beggs work seeks to bring clarity to the debate surrounding CCSVI by
characterizing physiological changes associated with constricted cerebral venous
outflow. The work submitted here involves collaborative studies with Robert
Zivadinov (University of Buffalo), Paolo Zamboni (University of Ferrara), and Chih-
Ping Chung (National Yang Ming University of Medicine). The key findings of these
studies are: (i) MS patients, diagnosed with CCSVI, exhibit greatly increased
hydraulic resistance of the cerebral venous drainage system; (ii) MS patients
experience loss of the small cerebral veins; (iii) MS patients exhibit reduced CSF
bulk flow, consistent with mild venous hypertension; (iv) MS patients exhibit
increased CSF pulsatility in the Aqueduct of Sylvius, which appears to be linked
with mild venous hypertension associated with CCSVI; and (v) jugular venous reflux
is associated with white matter and parenchymal volumetric changes in Alzheimer’s
patients. Collectively, these findings suggest that extracranial venous anomalies are
associated with changes in the intracranial physiology.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/7321 |
| Date | January 2014 |
| Creators | Beggs, Clive B. |
| Contributors | Not named |
| Publisher | University of Bradford, School of Engineering |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Thesis, doctoral, PhD |
| Rights | <a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><img alt="Creative Commons License" style="border-width:0" src="http://i.creativecommons.org/l/by-nc-nd/3.0/88x31.png" /></a><br />The University of Bradford theses are licenced under a <a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/">Creative Commons Licence</a>. |
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