Stress-related cognitive changes are still a matter of debate. In some
particular neuropathological conditions such as focal ischemia, cognitive
functions have been shown to be significantly impaired. These conditions,
however, may be improved by some factors such as steroid hormones. The
purpose of the current thesis was to assess the structural and functional effects
of corticosterone-related experiences on the hippocampus before and after
endothelin-1 (ET-1)-induced stroke. We found corticosterone-related experiences
enhance the hippocampal recovery, and improve its function in both wet and dryland
tasks after ET-1-induced focal stroke. Structural and functional effects of
such experiences prior to the focal ischemia in the hippocampus, however,
showed that stress, not corticosterone is a strong inhibitor for hippocampal
recovery. / xii, 252 leaves : ill. ; 29 cm. --
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:ALU.w.uleth.ca/dspace#10133/725 |
| Date | January 2008 |
| Creators | Faraji, Jamshid, University of Lethbridge. Faculty of Arts and Science |
| Contributors | Sutherland, Robert, Metz, Gerlinde |
| Publisher | Lethbridge, Alta : University of Lethbridge, Faculty of Arts and Science, 2008, Arts and Science, Neuroscience |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | en_US |
| Detected Language | English |
| Type | Thesis |
| Relation | Thesis (University of Lethbridge. Faculty of Arts and Science) |
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