Five new diterpenes, GN67-12-5-4-2 (1)¡BGN67-12-6-4-2 (2)¡BGN67-20-4-3 (3)¡BGN67-25-6-1 (4)¡BGN67-12-5-12-1 (5) and four known terpenoides, GN67-12-5-12 (6)¡BGN67-28-5-3-3 (7)¡BGN67-28-5-4 (8)¡BGN67-23-4 (9) were isolated from the methylene chloride solubles of the Formosan soft coral Cespitularia hypotentaculata.
Three new cytotoxic sesquiterpenes, GN78-14-3a-B (10)¡BGN78-22-8I-B (11)¡BGN78-17-3a-B (12) and five known terpenoides, GN78-12-5-B-G (13)¡BGN78-14-3a-N (14)¡BGN78-22-8-W (15)¡BGN78-22-8-H (16)¡BGN78-24-5-Q (17) were isolated from the Formosan soft coral Paralemnalia thyrsodes
Three known compounds, GN72-9-8-J (18)¡BGN72-7-4-2 (19)¡BGN72-19-6-8-E (20) were isolated from the methylene chloride solubles of the Formosan soft coral Dendronephthya divaricata
The structure of 4 was further confirmed by X-ray crystallographic analysis and the configuration of the hydroxyl at C-6 of 5 was further determined by Mosher¡¦s reactions. It was suggested that the C-6 has the S configuration.
The inhibition of these metabolites toward the pro-inflammatory proteins (iNOS and COX-2) expression was also investigated. Compound 17 showed more specific inhibition against the up-regulation of the pro-inflammatory iNOS protein of LPS-stimulated RAW264.7 macrophage cells.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0907107-171210 |
| Date | 07 September 2007 |
| Creators | Lin, En-hung |
| Contributors | Ping-Jyun Sung, Chang-Yih Duh, Zhi-Hong Wen |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0907107-171210 |
| Rights | not_available, Copyright information available at source archive |
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