New Zealand albino rabbits exhibited calcified aortic plaques and maximum average serum cholesterol levels of 1200 mg percent after twenty-three weeks on an atherogenic diet (250 to 500 mg percent cholesterol in ten percent corn oil; 200,00 I.U. vitamin D3 per month). One month following termination of the atherogenic diet, rabbits were treated with disodium edetate (Na2EDTA, 50 mg/kg body weight) via the marginal ear vein, on alternating days for a total of twenty infusions each. Aortae were examined for tissue calcium both quantitatively (direct microcomplexometric analysis) and histologically six weeks after completion of EDTA chelation therapy.
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc798053 |
| Date | 05 1900 |
| Creators | Walker, Foster M. |
| Publisher | North Texas State University |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | Text |
| Rights | Public, Copyright, Copyright is held by the author, unless otherwise noted. All rights |
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