The object of this investigation was firstly to compare the three methods for the preparation of quinolinic acid (pyridine 2,3-dicarboxylic acid), namely, the oxidation of quinoline in a water solution either by potassium permanganate or hydrogen peroxide and the oxidation of 8-hydroxy quinoline with nitric acid at low temperatures. The first method seemed to be the most desirable since quinoline from coal-tar is an inexpensive material and potassium permanganate costs less than hydrogen peroxide. Previous publications dealing with this oxidation give low and inconsistent yields. Therefore, it was of interest to improve the method of oxidation of quinoline with potassium permanganate. The other problem in this research was to study the condensation of diethyl quinolate and ethyl acetate with basic catalysts in order to obtain derivatives of the pyrindene series.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.124014 |
| Date | January 1952 |
| Creators | Dennis, Donald Albert. |
| Contributors | Taurins, A. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science. (Department of Chemistry.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001172200, Theses scanned by McGill Library. |
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