Lipids are loosely defined as a group of naturally occurring organic compounds which are hydrophobic or amphipathic in nature, but which are also readily soluble in organic solvents. These solubility features are present in an extremely heterogeneous collection of molecules such as fatty acids, phospholipids, eicosanoids, and sterols. The functions of various lipids are diverse and wide ranging, and many are considered essential for standard life functions. Despite their importance within biological processes, many lipids are also susceptible to free radical oxidation and degradation in the presence of reactive oxygen species. This lipid oxidation, commonly referred to as lipid peroxidation, can have extensive physiological consequences and can play a role in the progression of human disease states such as Parkinsonâs disease and atherosclerosis.
The focus of this dissertation is centered around the free radical oxidation of polyunsaturated fatty acids (PUFAs). We present several kinetic studies probing the rates at which these reactions occur are reported for a wide variety of PUFAs and sterols. We also highlight physical studies involving isotopically reinforced polyunsaturated fatty acids and assess their ability to reduce levels of free radical oxidation both in solution and in biological systems.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-05242017-211349 |
| Date | 26 May 2017 |
| Creators | Lamberson, Connor Reid |
| Contributors | Lawrence J. Marnett, Ned A. Porter, Brian O. Bachmann, John A. McLean |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-05242017-211349/ |
| Rights | restricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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