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Cyclodextrins as potential human anti-atherosclerotic agents

Cyclodextrins (CDs) are naturally occurring cyclic oligosaccharides. Since it is believed that OxC blocks the removal of normal cholesterol from cells in the artery wall, it is possible that selective removal of OxC in the vessel wall in-vivo may prevent or reverse atherosclerosis.As a prelude to major studies, this research project was designed to answer two critical questions; 1/. What is the best route for delivery of CD. 2/. How do animals (apoE-/- mice) tolerate it. Pilot studies were established and results noted. These studies have provided valuable information in the apoE-/- mouse for subsequent studies to prevent or reverse atherosclerosis in this animal model. / Master of Science (Hons)

Identiferoai:union.ndltd.org:ADTP/181669
Date January 2001
CreatorsMartinic, Goran (Gary), University of Western Sydney, Hawkesbury, College of Science, Technology and Environment, School of Environment and Agriculture
Source SetsAustraliasian Digital Theses Program
LanguageEnglish
Detected LanguageEnglish
SourceTHESIS_CSTE_EAG_Martinic_G.xml

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