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<strong>Demonstration of Choroid  Plexus-Subventricular Zone Regulatory (CSR) Axis Mediated by Small  Extracellular Vesicles: Toxicological, Molecular, and Neurobehavioral  Characterizations</strong>

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<p>The choroid plexus (CP) in brain ventricles secrete cerebrospinal fluid (CSF) that bathes the adjacent subventricular zone (SVZ); the latter is the largest neurogenic region in adult brain harboring neural stem/progenitor cells (NSPCs) and supplies newborn neurons to the olfactory bulb (OB) for normal olfaction. We discovered the presence of a CP-SVZ regulatory (CSR) axis in which the CP, by secreting small extracellular vesicles (sEVs), regulated adult neurogenesis in the SVZ and maintained olfaction. The proposed CSR axis was supported by 1) differential neurogenesis outcomes in the OB when animals treated with intracerebroventricular (ICV) infusion of sEVs collected from the CP of normal or manganese (Mn)-poisoned mice, 2) progressively diminished SVZ adult neurogenesis in mice following CP-targeted knockdown of SMPD3 to suppress CP sEV secretion, and 3) compromised olfactory performance in these CP-SMPD3-knockdown mice. Collectively, our findings demonstrate the biological and physiological presence of this sEV-dependent CSR axis in adult brains.</p>

  1. 10.25394/pgs.22706119.v1
Identiferoai:union.ndltd.org:purdue.edu/oai:figshare.com:article/22706119
Date29 April 2023
CreatorsLuqing Liu (15363706)
Source SetsPurdue University
Detected LanguageEnglish
TypeText, Thesis
RightsCC BY 4.0
Relationhttps://figshare.com/articles/thesis/_strong_Demonstration_of_Choroid_Plexus-Subventricular_Zone_Regulatory_CSR_Axis_Mediated_by_Small_Extracellular_Vesicles_Toxicological_Molecular_and_Neurobehavioral_Characterizations_strong_/22706119

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