Magister Scientiae (Medical Bioscience) - MSc(MBS) / This study investigated the effect of the C. capensis extract (0.001, 0.01, 0.1, 1, 10, 100 1000 μg/ml) on LNCaP prostate cancer, TM3 Leydig and TM4 Sertoli cells for 24 and 96 hours. The following parameters were investigated: morphology, cell viability (XTT), testosterone modulation, DNA fragmentation (TUNEL), lactate dehydrogenase activity (LDH), testosterone production, anti-cancer drug combination. In a separate set of experiments, parameters affecting the initiation, progression and metastasis of cancer were investigated. These included the ability of the aqueous C. capensis rhizome extract to inhibit of reactive oxygen species (ROS) and reactive nitrogen species (RNS) production, and to inhibit collagenase and elastase activity.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uwc/oai:etd.uwc.ac.za:11394/4307 |
| Date | January 2014 |
| Creators | Pearce, Keenau Mark |
| Contributors | Henkel, R, Hiss, D |
| Publisher | University of the Western Cape |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Rights | University of the Western Cape |
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