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Efficacy of Nikkomycin Z for respiratory coccidioidomycosis in naturally infected dogs

Nikkomycin Z (NikZ) is a chitin synthase inhibitor with antifungal efficacy against Coccidioides spp. and other endemic fungi. Dogs suffer a rate and range of natural coccidioidomycosis similar to humans and were considered an excellent model for initially testing NikZ against naturally acquired disease. Twelve dogs with coccidioidal pneumonia that had been present for an average of three months were treated with 250 mg (5 - 15 kg) or 500 mg (> 15 - 30 kg) twice daily for 60 days. Nine dogs completed the course of treatment and seven dogs had improvement in disease based on radiographs, clinicopathological parameters, physical examination findings, and subjective assessment by the owners; three dogs had resolution or near resolution of disease. Based on this small study, NikZ shows efficacy to treat naturally acquired coccidioidomycosis and merits further development for trials in humans.

Identiferoai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/621447
Date10 1900
CreatorsShubitz, Lisa, Roy, Michael E, Nix, David, Galgiani, John N.
ContributorsThe University of Arizona
Source SetsUniversity of Arizona
Languageen_US
Detected LanguageEnglish
TypeDataset
RightsCopyright © Arizona Board of Regents.

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