Yes / Solid state shear milling (S3M) is reported as a scalable, continuous, polymer-assisted cocrystallization technique. A specially designed milling pan was employed to provide high levels of applied shear, and the addition of a polymeric processing aid enabled generation of high stress fields. Carbamazepine–salicylic acid cocrystals were produced with 5–25 wt % of poly(ethylene oxide) (PEO). A systematic study was carried out to understand the effect of process variables on properties and performance of the cocrystals. S3M offers an important new route for continuous manufacturing of pharmaceutical cocrystals.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/15301 |
| Date | 13 March 2018 |
| Creators | Korde, Sachin A., Pagire, Sudhir K., Pan, H., Seaton, Colin C., Kelly, Adrian L., Chen, Y., Wang, Q., Coates, Philip D., Paradkar, Anant R |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Accepted Manuscript |
| Rights | © 2018 ACS. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.cgd.7b01733. |
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