The advantage of one-bead-one-compound combinatorial libraries is that hundreds of thousands to millions of compounds can be rapidly synthesized and screened simultaneously. The beads supporting the compounds of interest are then isolated and analyzed to decipher the structure of the desired compound. Many methods are currently used to allow deconvolution of the compound on the individual beads. Herein is described a novel method to encode TentaGel beads using absorption of different ratios of lanthanide ions. The encoding process is completed in parallel with the synthesis of the library of compounds. Once the desired beads are identified, the lanthanide ions can be released from the bead and analyzed using Inductively Coupled Plasma-Mass Spectrometry (ICP-MS).
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/26442 |
| Date | 02 March 2011 |
| Creators | Ng, Grace Pik Ling |
| Contributors | Nitz, Mark |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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