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Synthesis and Biological Evaluation of Enediyne Containing Combretastatin A-4 Analogues

We synthesized a series of enediyne containing Combretastatin A-4 analogues and evaluated the growth inhibitory activity of analogues against two human hepatoma cell lines (Hep G2, Hep 3B), two breast cancer cell lines (MDA-MB-231, MCF-7) and human lung cancer cell line (A-549). It was found that compounds 39a, 39d, 39e, 39f and 40a produced growth inhibitory activity for the five human cancer cell lines. Among them, compound 40a showed the best inhibitory activity (IC50 = 0.8 £gM for A-549 and IC50 = 8.53 £gM for Hep 3B) which were comparable to the Combretastatin A-4 (IC50 = 1.57 £gM for A-549 and IC50 = 14.32 £gM for Hep 3B).

Identiferoai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0706111-163900
Date06 July 2011
CreatorsHuang, I-Hua
ContributorsTzeng, Cherng-Chyi, Wu, Ming-Jung, Ong, Chi-Wi
PublisherNSYSU
Source SetsNSYSU Electronic Thesis and Dissertation Archive
LanguageCholon
Detected LanguageEnglish
Typetext
Formatapplication/pdf
Sourcehttp://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0706111-163900
Rightsnot_available, Copyright information available at source archive

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