A series of anilines and enediynes containing Combretastatin A-4 analogues were synthesized. The growth inhibitory activity of these analogues were evaluated against three human cancer cell lines including human hepatoma (Hep G2), breast cancer (MBA-MB231) and lung cancer (A-549) cell lines. The IC50 values of the synthesized compounds are between 10-5-10-7 £gM. We found that compounds 11e, 12e and 13e were observed good growth inhibitory activity for the three human cancer cell lines, especially for A549 (IC50 = 0.22, 0.40 and 0.16 £gM respectively).
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0719112-113520 |
| Date | 19 July 2012 |
| Creators | Lin, Jia-ying |
| Contributors | Ming-Jung Wu, Po-Chiao Lin, Chung-Ming Sun |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0719112-113520 |
| Rights | user_define, Copyright information available at source archive |
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