The objective of the present study was to investigate deformational behavior and functional adaptation of articular cartilage by comparing the changes of biochemical osteoarthritis markers&rsquo / concentrations due to 30-min exercise after 12-weeks of regular high impact, impact or non-impact exercise.
Blood samples were drawn from 44 healthy sedentary males immediately before, immediately after and 0.5 h after a 30-min moderate walking exercise. Osteoarthritis biomarkers&rsquo / (Serum COMP and CTX-I) concentrations were determined with enzyme-linked immunosorbent assay. After the first measurements, participants were randomly assigned to running, cycling, swimming, and control groups. All groups except for control group trained for 12 weeks. After 12-weeks, post tests were applied.
Multivariate tests indicated a significant fatigue and resting effect on serum COMP concentration in all groups at pre- and post-tests. Therefore, pair wise comparisons were conducted in order to assess the differences across all groups and conditions. Results indicated significant differences in post-test measurements among phases of groups except for running group. However, fatigue or resting did not change the concentration of serum CTX-I in any groups during the tests.
According to results, moderate walking activity has an influence on the increase of serum COMP concentrations of young sedentary men. However, 12 weeks regular weight-bearing high impact physical exercise decreases the deformational effect of walking activity by functional adaptation of articular cartilage to specific environmental requirements.
| Identifer | oai:union.ndltd.org:METU/oai:etd.lib.metu.edu.tr:http://etd.lib.metu.edu.tr/upload/12611551/index.pdf |
| Date | 01 January 2010 |
| Creators | Celik, Ozgur |
| Contributors | Korkusuz, Feza |
| Publisher | METU |
| Source Sets | Middle East Technical Univ. |
| Language | English |
| Detected Language | English |
| Type | Ph.D. Thesis |
| Format | text/pdf |
| Rights | To liberate the content for public access |
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