Thesis (DSc (Biochemistry))--Stellenbosch University, 2009. / The fumonisin mycotoxins are known to be the causative principle for several animal
diseases and are associated with the development of liver and oesophagus cancer
and neural tube defects in humans. The thesis focuses mainly on the
characterisation of the compounds from maize cultures of the fungus Fusarium
verticillioides, isolated from maize, the toxicological effects in animals, mechanism
involved in hepato- and nephrocarcinogenicity and discussing the major differences
and contradictions in the literature together with their impact on setting relevant risk
assessment parameters to safeguard human health. Controversies include the
importance of non-genotoxicity vs genotoxicity in the development of cancer, the role
of threshold effects in carcinogenesis and the establishment of realistic risk
assessment parameters that will also be applicable in developing countries. Recent
approaches suggest that thresholds should also apply for genotoxic carcinogens as
interaction with the DNA is only one event in the multi-step process of cancer
development and therefore could not be taken as the basis for applying a no-effect
threshold for genotoxins. It would appear that a carcinogen such as fumonisin,
whether it is labeled genotoxic or non-genotoxic per se, exhibits some degree of risk
at any level due to additive or synergistic interactions with other xenobiotics and/or
dietary constituents. The underlying mechanisms of fumonisin-induced
carcinogenicity includes the disruption of sphingolipid, phospholipids and fatty acid
metabolism, which plays a major role in the modulation of apoptotic and cell
proliferative pathways related to cancer development. Interactive responses between
arachidonic acid and ceramide affect downstream cell signal transduction pathways
and depending on the cell type the disruption of these pathways could either
stimulate or inhibit cell proliferation which eventually will determine the induction of
apoptosis and hence affect cell survival. The modulating roles of dietary constituents
such as vitamins, protein and the South African herbal teas are also highlighted as
they affected the outcome of toxicological assays, thus determining thresholds of the
adverse effects in specific target organs that will impact risk assessment parameters.
Regulation of the fumonisins in food and the associated risk are debated from many
perspectives. In developing countries there is a lack of quality control implying that
maize highly contaminated with mycotoxins may directly enter the food chain of
adults and children as control of mycotoxins is difficult or in some cases totally
absent. The interaction of politics, economy and technology will eventually determine
the impact on health as the regulation of fumonisin in food differs between countries.
Knowledge about the biological effects of the fumonisins is currently playing an
important role in the development of simple and inexpensive methods to reduce the
levels of the fumonisin in maize by targeting specific populations at risk.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:sun/oai:scholar.sun.ac.za:10019.1/3971 |
| Date | 03 1900 |
| Creators | Gelderblom, Wentzel Christoffel Andreas |
| Contributors | Swart, P. S., Marasas, W. F. O., Stellenbosch University. Faculty of Science. Dept. of Biochemistry. |
| Publisher | Stellenbosch : Stellenbosch University |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Rights | Stellenbosch University |
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