Atherosclerotic plaque caps are composed of a composite soft tissue material
that becomes subjected to cyclic loading under stenotic flow conditions.
The cyclic loading causes the plaque cap to fatigue and eventually fail. The
hypothesis of this work is that arteries and plaque caps may fatigue which may
be predicted by a stress vs. number of cycles (S-N) curve. The S-N curve has not
been determined for almost any biological soft tissue. The Specific Aim of the
thesis is to quantify an S-N curve for normal arterial soft tissue collected from
cyclic tension testing. Coronary arteries from porcine hearts will be tested as a
material that closely models the plaque cap in non-linear elastic behavior. The
S-N curve will be developed through failure testing with multiple cycles at
stresses between 0.5 and 5 MPa.
| Identifer | oai:union.ndltd.org:GATECH/oai:smartech.gatech.edu:1853/6912 |
| Date | 21 April 2005 |
| Creators | Gilpin, Crystal Marie |
| Publisher | Georgia Institute of Technology |
| Source Sets | Georgia Tech Electronic Thesis and Dissertation Archive |
| Language | en_US |
| Detected Language | English |
| Type | Thesis |
| Format | 810753 bytes, application/pdf |
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