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The role of suppressors of cytokine signalling 1 and 3 in macrophage activation

Macrophages (M?) are widely distributed immune cells and can be phenotypically polarised by microenvironment to mount specific functional programs. M? polarised in vitro can be broadly classified in two main groups: classically activated (or Ml), and alternatively activated (or M2) M?. M1 exhibit potent microbicidal properties and induce pro-inflammatory responses, whilst M2 play a role in resolution of inflammation and reduce pro-inflammatory responses.

Identiferoai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:493453
Date January 2008
CreatorsLiu, Yu
PublisherUniversity of Aberdeen
Source SetsEthos UK
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation
Sourcehttp://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=24848

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