>Magister Scientiae - MSc / Tyrosinase is an enzyme widely distributed in the biosphere and is found in many species of
bacteria, fungi, animals, and plants; it is associated with melanin production. Even though it
possesses many beneficial properties such as photoprotection, but overproduction causes
undesirable effects such melasma, solar lentigines etc. Therefore, tyrosinase enzyme inhibitors
are of far-ranging importance in cosmetics, medicinal products, and food industries.
This study is aimed to test anti-tyrosinase activity in 37 plants from 20 families using
mushroom tyrosinase inhibition method; each plant was extracted with methanol. The results
showed that 17 plant extracts, exerted a considerable level of in vitro tyrosinase inhibition
comparable to positive controls of kojic acid in the same solvent systems when evaluated
spectrophotometrically. Among plant extracts, those that showed an inhibition rate >50 % at
50 μg/ml and ˃60 % at 200 μg/ml were A. karroo (Hayne.), A. afra Jacq. Ex Willd, C.
geifolia (L.), E. racemosa (L.), H. petiolare Hilliard & B.L.Burt, M. quercifolia (L.), M.
communis (L.), P. rigida (Wikstr.), P. ecklonii (Benth.), P. ericoides (L.), S. Africanacaerulea
(L.), S. Africana-lutea (L.), S. antarcticus (Willd.), S. lucida (L.) F.A.Barkley, S.
hamilifolius (L.), S. furcellata R.Br and T riparia which exhibited great anti-tyrosinase
activity.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uwc/oai:etd.uwc.ac.za:11394/6531 |
| Date | January 2018 |
| Creators | Sonka, Luveni |
| Contributors | Mohammed, Ahmed H.A |
| Publisher | University of the Western Cape |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Rights | University of the Western Cape |
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