Arteries possess the ability to grow and remodel in response to sustained alterations
in biomechanical loading, likely via mechanisms that are similarly involved in
diverse arterial pathologies and responses to treatment. In particular, myriad experminental
observations suggest that cell and matrix turnover within vasoaltered states
enable arteries to adapt to sustained changes in mechanical stimuli. The goal herein
is to show explicitly how altered smooth muscle contractility and matrix growth and
remodeling work together to adapt the geometry, structure, stiffness, and function
of a representative basilar artery. This work seeks to illustrate the importance of
complementary vasoactivity and matrix remodeling for basilar arteries in response to
sustained alterations in mechanical stimuli. Toward this end, an extended constrained
mixture model of the arterial wall is employed whereby the mass fractions, material
properties, and natural configurations of individual constituents can evolve separately
and thereby dictate overall growth and remodeling. This approach accounts for fundamentally
important behaviors. Simulations provide important intuition and insight
regarding constitutive functional forms and model parameters.
| Identifer | oai:union.ndltd.org:tamu.edu/oai:repository.tamu.edu:1969.1/ETD-TAMU-2009-08-7051 |
| Date | 2009 August 1900 |
| Creators | Valentin, Auturo III |
| Contributors | Humphrey, Jay D. |
| Source Sets | Texas A and M University |
| Language | en_US |
| Detected Language | English |
| Type | Book, Thesis, Electronic Dissertation, text |
| Format | application/pdf |
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