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Změny v genomu viru klíšťové encefalitidy u variant s různou historií pasáží a odlišnými biologickými vlastnostmi / Genome changes of tick-borne encephalitis virus in variants with different passage history and biological properties

Tick-borne encephalitis virus (strain Hypr) was serially subcultured in PS cells and tick cell line IRE/CTVM19, producing four different viral variants. Biological properties of these new variants were investigated in mouse model. Possible determinants of virulence were found by full-genome sequencing. The role of glycosylation for tick-borne encephalitis virus was evaluated.

Identiferoai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:53938
Date January 2011
CreatorsSTROUHALOVÁ, Renata
Source SetsCzech ETDs
LanguageCzech
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/masterThesis
Rightsinfo:eu-repo/semantics/restrictedAccess

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